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X-Chromosome Hyperploidy in Couples With Multiple Spontaneous Abortions

From the Departments of Obstetrics, Gynecology, and Reproductive Sciences and of Pediatrics, University of California, San Francisco

Abstract

From 1973 to 1983, cytogenetic analyses were performed on blood samples from 144 couples referred because of two or more spontaneous abortions. Any couple with abnormal offspring in addition to the miscarriages was excluded from the study. Two balanced translocations were found in the 288 individuals examined (0.7%). There was a high frequency of phenotypically normal individuals with cells hyperploid for the X chromosome. This may be a manifestation of an impaired genetic control of chromosome disjunction in these patients.

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