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Obstetrics & Gynecology 1983;62:667-669
© 1983 by The American College of Obstetricians and Gynecologists
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AUTOIMMUNITY IN A PATIENT WITH 47,XXX KARYOTYPE

Daniel P. Michalak, MD, Howard A. Zacur, MD, PhD, John A. Rock, MD and J. Donald Woodruff, MD

Department of Gynecology and Obstetrics, The Johns Hopkins Hospital, Baltimore, Maryland.

Abstract

Premature ovarian failure in women with a 47, XXX karyo-type have been described, but an explanation for this gonadal disorder has not been forthcoming. The present case identifies a 47 triple X woman with premature ovarian failure associated with an autoimmune disorder. A possible association between the 47, XXX karyotype, autoimmune disorders, and premature ovarian failure is proposed.






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