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From the Division of Oncology, Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
Two hundred forty patients, ages 12 to 54 years, with biopsyconfirmed early cervical intraepithelial neoplasia (CIN 1) treated by cryosurgery were reviewed. CIN 1 has been viewed historically as having high rates of remission or stabilization. The initial cure rate was 89%, with a 97% cure rate after retreatment of failures. All failures were confirmed histologically. The initial cure rates are no better than those for higher grades of CIN. Thus, CIN I should be viewed with the same seriousness as CIN II or CIN III.
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