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Association of Human Papillomavirus Infection With Cervical Intraepithelial Neoplasia

From the Departments of Obstetrics and Gynecology and of Pathology, State University of New York, Downstate Medical Center, Brooklyn, New York.

Human papillomavirus infections of the cervix were assessed in patients attending a colposcopy clinic. Of 348 patients with cervical biopsies, 134 (38.5%) had human papillomavirus infections, and of 251 patients with cervical intraepithelial neoplasia (CIN) 112 (44.6%) had human papillomavirus. The majority of patients with human papillomavirus had concurrent CIN (83.6%; 112/134). Patients with human papillomavirus were significantly younger than patients without human papillomavirus (24.4 versus 29.9 years mean age; P < .001), had significantly milder degrees of CIN (84% versus 43% mild/moderate dysplasia; P < .001), and had a significantly lower mean number of pregnancies (2.16 versus 3.05; P <.001). A matched pairs analysis of 69 pairs showed the same distribution of CIN in both human papillomavirus and nonhuman papillomavirus patients. Electron microscopy of human papillomavirus-specific koilocytes confirmed the presence of human papillomavirus particles in the nuclei.