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Obstetrics & Gynecology 1983;62:S83-S87
© 1983 by The American College of Obstetricians and Gynecologists
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Human Papilloma Virus in Multifocal, Invasive Female Genital Tract Malignancy

JOHN C. WEED, Jr, MD, CYNTHIA LOZIER, MD and SARA JO DANIEL, MD

From the Departments of Obstetrics and Gynecology ami of Pathology, University of South Alabama College of Medicine, Mobile, Alabama, Duke University, Durham, North Carolina/ and Mostellar Medical Clinic, Bayou La Batre, Alabama

Abstract

Two young patients with multifocal, invasive, verrucoid carcinomas of the lower genital tract are described. Viral particles consistent with human papilloma virus were demonstrated by transmission electron microscopy in areas of koilocytotic malignant and nonmalignant epithelium, and both patients had evidence of impaired immune function. The role of human papilloma virus in genital neoplasia is discussed.






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