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Obstetrics & Gynecology 1983;62:S35-S37
© 1983 by The American College of Obstetricians and Gynecologists
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Cryptococcal Meningitis in Pregnancy

CHARLES R. STAFFORD, MD, JOHN F. FISHER, MD, HOSSAM E. FADEL, MD, V. ESPINEL-INGROFF, MS, SMITH SHADOMY, PhD and MARY HAMBY, MD

From the Department of Obstetrics and Gynccology, Medical College of Georgia, Augusta, Georgia.

Abstract

Cryptococcal meningitis was diagnosed in a pregnant woman at 21 weeks' gestation. The availability of fetal tissues, blood, and amniotic fluid in such a patient receiving therapy with amphotericin B plus flucytosine afforded the opportunity to study the effects of the disease and therapeutic agents on the developing fetus. The amphotericin B concentration in amniotic fluid was 0.25 µ/ml and that of flucytosine was 168 µ/ml. The concentrations in cord blood were 0.3 µ/ml and 64.7 µ/ml, respectively. No evidence was found of amphotericin B or flucytosine toxicity in fetal tissues, although exposure of the fetus to these compounds was of brief duration.






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