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Fatal Herpetic Hepatitis in Pregnancy

From the Departments of Obstetrics and Gynecology, Medicine, and Pathology, Louisiana State University School of Medicine, New Orleans, Louisiana; and the Departments of Medicine and Pathology, University of North Carolina, Chapel Hill, North Carolina.

Disseminated herpetic infections are becoming more commonly reported during pregnancy. Such infections almost always occur in the third trimester and are usually associated with a primary infection, which serves as a portal of entry. Because of the high fetal and maternal mortality associated with this condition, early diagnosis and treatment are essential. Disseminated herpesvirus infection must be considered whenever a pregnant patient has herpetic mucocutaneous lesions, vague systemic symptoms, or evidence of massive hepatic dysfunction.