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Diagnostic Reliability of Mi-Mark Helix Technique in Endometrial Neoplasia

From the Division of Gynecologic Oncology. Department of Obstetrics and Gynecology; and the Division of Cytology. Department of Pathology, Michael Reese Hospital and Medical Center, Pritzer School of Medicine, University of Chicago, Chicago, Illinois

Abstract

To evaluate the diagnostic reliability of the Mi-Mark helix technique in endometrial neoplasia, 138 women with abnormal uterine bleeding underwent a prospective study of Mi-Mark sampling of the uterine cavity before dilatation and curettage. Of one hundred thirty-eight patients, 42% had postmenopausal bleeding and 18% had perimenopausal bleeding. The acceptability of this procedure by patients and physicians was remarkable. All invasive endometrial carcinomas were detected by Mi-Mark cytology. The most serious limitation of this technique was its failure to detect a large number of hyperplasias without atypia. Examination of a cell block along with cytology would facilitate the histopathologic diagnosis, especially of hyperplasia. The results of this study appear to justify the use of this procedure in high-risk patients.