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ISOLATION OF AMNIOTIC FLUID ERYTHROCYTES AND THEIR POSSIBLE USE IN PRENATAL DIAGNOSIS

From the Department of Cell and Molecular Biology and the Maternal- Fetal Medicine Section, Department of Obstetrics and Gynecology, Medical College of Georgia, Augusta, Georgia

Many of the components of amniotic fluid have been found to be valuable in prenatal diagnosis; however, the presence of erythrocytes is usually considered undesirable. The authors have used buoyant density centrifugation on 96 amniotic fluid specimens from 70 subjects to isolate small numbers of erythrocytes from a majority of these specimens. Through immunofluorescence, these specimens were found to have higher levels of fetal hemoglobin-containing cells than the adult, indicating that the erythrocytes were at least in part fetal in origin. Thus, erythrocytes present in amniotic fluid could also be used in prenatal diagnosis.