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Obstetrics & Gynecology 1983;61:529-533
© 1983 by The American College of Obstetricians and Gynecologists
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ISOLATED GONADOTROPIN DEFICIENCY IN THREE SISTERS

J Paul Lock, MD, Larry Penney, MD, Muhamed Jawadi, MD and George Betz, MD, PhD

From the Division of Endocrinology, Departments of Medicine and Obstetrics and Gynecology, University of Colorado School of Medicine, Denver, Colorado

Abstract

Three female siblings with isolated gonadotropin deficiency were studied. None demonstrated hyposmia or craniofacial abnormalities. Single doses of luteinizing hormone-releasing hormone and thyrotropin-releasing hormone (TRH) produced markedly different responses within the kindred. Following administration of TRH, one subject displayed a sharp rise in prolactin, but thyrotropin did not change.






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Copyright © 1983 by the American College of Obstetricians and Gynecologists.