| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Division of Obstetrics and Medical Gynecology and the Department of Medical Statistics and Epidemiology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota
Abstract
Ovarian hormones have been implicated in a number of neoplastic conditions. Chronic anovulation syndrome, a spontaneous biologic experiment of unopposed secretion of estrogen by the ovaries, was identified in a cohort of 1270 patients, and the risk of these patients having neoplasia was studied. Of the 1270 patients studied, 30 had a subsequent malignancy develop; the expected number was 29.8. When the individual types of subsequent malignancy were analyzed, the endometrium was the only site at increased risk. The relative risk of developing carcinoma of the endometrium after the diagnosis of chronic anovulation syndrome is 3.1 (95% confidence interval 1.1 to 7.3). The long-term risk of developing adenocarcinoma of the endometrium might be considered when treating patients who have this syndrome.
This article has been cited by other articles:
|
|
 |
|
  C. M Olsen, A. C Green, C. M Nagle, S. J Jordan, D. C Whiteman, C. J Bain, P. M Webb, and on behalf of the Australian Cancer Study Group (Ov Epithelial ovarian cancer: testing the 'androgens hypothesis' Endocr. Relat. Cancer, December 1, 2008; 15(4): 1061 - 1068. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Pappo, L. Lerner-Geva, A. Halevy, L. Olmer, S. Friedler, A. Raziel, M. Schachter, and R. Ron-El The Possible Association between IVF and Breast Cancer Incidence Ann. Surg. Oncol., April 1, 2008; 15(4): 1048 - 1055. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Meyer, B. P. McGrath, and H. J. Teede Effects of Medical Therapy on Insulin Resistance and the Cardiovascular System in Polycystic Ovary Syndrome Diabetes Care, March 1, 2007; 30(3): 471 - 478. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Terry, W. C. Willett, J. W. Rich-Edwards, and K. B. Michels A Prospective Study of Infertility Due to Ovulatory Disorders, Ovulation Induction, and Incidence of Breast Cancer Arch Intern Med, December 11, 2006; 166(22): 2484 - 2489. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Wierman, R. Basson, S. R. Davis, S. Khosla, K. K. Miller, W. Rosner, and N. Santoro Androgen Therapy in Women: An Endocrine Society Clinical Practice Guideline J. Clin. Endocrinol. Metab., October 1, 2006; 91(10): 3697 - 3710. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. A Christy, A. S Franks, and L B. Cross Spironolactone for Hirsutism in Polycystic Ovary Syndrome Ann. Pharmacother., September 1, 2005; 39(9): 1517 - 1521. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Terry, W. C. Willett, J. W. Rich-Edwards, D. J. Hunter, and K. B. Michels Menstrual Cycle Characteristics and Incidence of Premenopausal Breast Cancer Cancer Epidemiol. Biomarkers Prev., June 1, 2005; 14(6): 1509 - 1513. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Vrbikova and D. Cibula Combined oral contraceptives in the treatment of polycystic ovary syndrome Hum. Reprod. Update, May 1, 2005; 11(3): 277 - 291. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Brinton, B. Scoccia, K. S. Moghissi, C. L. Westhoff, M. D. Althuis, J. E. Mabie, and E. J. Lamb Breast cancer risk associated with ovulation-stimulating drugs Hum. Reprod., September 1, 2004; 19(9): 2005 - 2013. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Legro, E. Myers, and for the Reproductive Medicine Network Surrogate end-points or primary outcomes in clinical trials in women with polycystic ovary syndrome? Hum. Reprod., August 1, 2004; 19(8): 1697 - 1704. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Somboonporn and S. R. Davis Testosterone Effects on the Breast: Implications for Testosterone Therapy for Women Endocr. Rev., June 1, 2004; 25(3): 374 - 388. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. T. Sheehan Polycystic Ovarian Syndrome: Diagnosis and Management Clin. Med. Res., February 1, 2004; 2(1): 13 - 27. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Siegelmann-Danieli, A. Tamir, H. Zohar, M. Z. Papa, L. L. Chetver, Z. Gallimidi, M. E. Stein, and A. Kuten Breast Cancer in Women With Recent Exposure to Fertility Medications is Associated With Poor Prognostic Features Ann. Surg. Oncol., November 1, 2003; 10(9): 1031 - 1038. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. De Leo, A. la Marca, and F. Petraglia Insulin-Lowering Agents in the Management of Polycystic Ovary Syndrome Endocr. Rev., October 1, 2003; 24(5): 633 - 667. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Diamanti-Kandarakis, J.-P. Baillargeon, M. J. Iuorno, D. J. Jakubowicz, and J. E. Nestler A Modern Medical Quandary: Polycystic Ovary Syndrome, Insulin Resistance, and Oral Contraceptive Pills J. Clin. Endocrinol. Metab., May 1, 2003; 88(5): 1927 - 1932. [Full Text] [PDF]
|
|
|
|
|
|
R. Kaaks, A. Lukanova, and M. S. Kurzer Obesity, Endogenous Hormones, and Endometrial Cancer Risk: A Synthetic Review Cancer Epidemiol. Biomarkers Prev., December 1, 2002; 11(12): 1531 - 1543. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Lunde, O. Djoseland, and P. Grottum Polycystic ovarian syndrome: a follow-up study on fertility and menstrual pattern in 149 patients 15-25 years after ovarian wedge resection Hum. Reprod., July 1, 2001; 16(7): 1479 - 1485. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Smith, A. C. von Eschenbach, R. Wender, B. Levin, T. Byers, D. Rothenberger, D. Brooks, W. Creasman, C. Cohen, C. Runowicz, et al. American Cancer Society Guidelines for the Early Detection of Cancer: Update of Early Detection Guidelines for Prostate, Colorectal, and Endometrial Cancers: ALSO: Update 2001--Testing for Early Lung Cancer Detection CA Cancer J Clin, January 1, 2001; 51(1): 38 - 75. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. J. Suh-Burgmann and A. Goodman Surveillance for Endometrial Cancer in Women Receiving Tamoxifen Ann Intern Med, July 20, 1999; 131(2): 127 - 135. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
