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Obstetrics & Gynecology 1983;61:S35-S37
© 1983 by The American College of Obstetricians and Gynecologists
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Unfavorable Neonatal Outcome After Intraamniotic Injection of Methylene Blue

JAMES K. McENERNEY, MD and LINDA N. McENERNEY, MD

From the Department of Obstetrics and Gynecology, Pritzer School of Medicine, University of Chicago; and the Department of Pediatrics, Chicago Medical School, Cook County Hospital, Chicago, Illinois

Abstract

A case is presented in which methylene blue dye was injected intraamniotically to confirm rupture of the membranes. Significant neonatal morbidity occurred as a direct result of the methylene blue dye injection. A syndrome of toxic side effects is described including hemolytic anemia, hyperbilirubinemia, and methemoglobinemia. The metabolic process is discussed. The authors suggest discontinuing the intraamniotic injection of methylene blue dye as a diagnostic aid. (Obstet Gynecol 61:35S, 1983)






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Copyright © 1983 by the American College of Obstetricians and Gynecologists.