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Obstetrics & Gynecology 1983;61:379-382
© 1983 by The American College of Obstetricians and Gynecologists
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DISCORDANT PREGNANCY TESTS IN DETECTION OF ALPHA-SUBUNIT-PRODUCING TUMORS

Norihiko Morimoto, MD, Mitsuru Ozawa, MD, Ryuichiro Nishimura, MD, Tamotsu Hamamoto, MD and Shimpei Tojo, MD

From the Department of Obstetrics and Gynecology, Osaka National Hospital, Osaka; and the Department of Obstetrics and Gynecology, Kobe University, School of Medicine, Kobe, japan

Ectopic production of isolated a-subunit of glycoprotein hormones was detected in a 32-year-old Japanese woman with metastatic lung tumor by a discordance in the immunologic pregnancy tests for native human chorionic gonadotropin (hCG) assays. Quantitative discrepancy of titrations among different types of pregnancy tests, ie, competitive (hemagglutination or latexagglutination inhibition) and noncompetitive (hemagglutination or latexagglutination) reactions, was also confirmed experimentally using a highly purified ectopic {alpha} -subunit from the patient's urine. Thus the discrepancy between the 2 types of assay systems was due, at least partly, to a cross-reaction of high concentrations (20,000 mg/ml) of ectopically secreted free a-subunit of glycoprotein hormones.






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