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Obstetrics & Gynecology 1983;61:320-326
© 1983 by The American College of Obstetricians and Gynecologists
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Clinical Significance of Estrogen and Progestin Receptors in Ovarian Cancer

ANTTI KAUPPILA, MD, PIRKKO VIERIKKO, MSc, SEPPO KIVINEN, MD, FREJ STENBÄCK, MD and REIJO VIHKO, MD

From the Departments of Obstetrics and Gynecology, Clinical Chemistry, and Pathology, University of Oulu, Oulu, Finland

Abstract

Concentrations of cytosol estrogen and progestin receptors were determined in ovarian carcinoma samples from 84 patients with early (stages I to II; N = 17), advanced (III to IV; N = 39), recurrent epithelial (N = 9), and nonepithelial (N = 5), cancer and with ovarian metastases of other malignancies (N = 11). Seventy-one percent of all the specimens contained estrogen and progestin receptors (3 or more and 6 or more fmol/mg cytosol protein, respectively, receptorpositive group), whereas 10% of the tumors were receptornegative. Primary epithelial ovarian carcinomas were more often receptor-positive (81% versus 44%), and they had higher receptor concentrations than recurrent epithelial ovarian tumors. Primary endometrioid and serous carcinomas had higher concentrations of cytosol estrogen receptors than did mucinous tumors. Anaplastic endometrioid malignancies had significantly lower concentrations of both receptors than the differentiated tumors, whereas in serous carcinomas only cytosol progestin receptor displayed this difference. Patients with advanced malignancy characterized by low estrogen and/or progestin receptor concentrations had nonremovable tumor more often, and they survived for a shorter time than the other patients.




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L. J. Havrilesky, C. P. McMahon, E. K. Lobenhofer, R. Whitaker, J. R. Marks, and A. Berchuck
Relationship Between Expression of Coactivators and Corepressors of Hormone Receptors and Resistance of Ovarian Cancers to Growth Regulation by Steroid Hormones
Reproductive Sciences, April 1, 2001; 8(2): 104 - 113.
[Abstract] [PDF]


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Copyright © 1983 by the American College of Obstetricians and Gynecologists.