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Obstetrics & Gynecology 1983;61:279-284
© 1983 by The American College of Obstetricians and Gynecologists
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Testosterone/Androstenedione Ratio in the Evaluation of Women With Ovarian Androgen Excess

R HERBERT WIEBE, MD and CATHERINE V. MORRIS, BSc

From the Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of South Alabama, Mobile, Alabama; and the Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina

Abstract

A plasma testosterone/androstenedione (T/A) ratio was calculated in 15 women with possible ovarian neoplasms and androgen excess and whose mean plasma concentration of testosterone approached or was greater than a twofold elevation. The T/A ratio approached unity in eight of nine patients with polycystic ovarian disease, whereas all patients with hyperthecosis and two of three patients with androgen-secreting tumors had a testosterone/androstenedione ratio above 1.5. In 13 of 16 patients with androgensecreting tumors of the ovary reported in the literature, the testosterone/androstenedione ratio was above 1.5. An elevated testosterone/androstenedione ratio should raise the suspicion of either an ovarian androgen-secreting tumor or hyperthecosis.




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J. F. Couse, M. M. Yates, K. F. Rodriguez, J. A. Johnson, D. Poirier, and K. S. Korach
The Intraovarian Actions of Estrogen Receptor-{alpha} Are Necessary to Repress the Formation of Morphological and Functional Leydig-Like Cells in the Female Gonad
Endocrinology, August 1, 2006; 147(8): 3666 - 3678.
[Abstract] [Full Text] [PDF]


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