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Obstetrics & Gynecology 1983;61:59-62
© 1983 by The American College of Obstetricians and Gynecologists
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Cervical Papillomavirus Infection in Diethylstilbestrol-Exposed Progeny

YAO S. FU, MD, WAYNE D. LANCASTER, PhD, RALPH M. RICHART, MD, JAMES W. REAGAN, MD, CHRISTOPHER P. CRUM, MD and RICHARD U. LEVINE, MD

From The Institute of Pathology, Case Western Reserve University, Cleveland, Ohio
From the Departments of Obstetrics and Gynecology and of Pathology, Georgetown University School of Medicine, Washington, DC.
From the Department of Pathology, Columbia University College of Physicians and Surgeons, New York, New York

Abstract

Histologic sections from cervical and vaginal biopsies showing dysplasia in 37 women exposed to diethylstilbestrol (DES) in utero were stained for human papillomavirus structural antigens using an immunoperoxidase technique. Forty-three percent of the lesions had detectable papillomavirus antigens. These findings indicate that a significant proportion of cervical dysplasia observed in DES-exposed progeny is associated with papillomavirus infection.






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