HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Ghosh, T K Articles by Cera, P J Search for Related Content PubMed PubMed Citation Articles by Ghosh, T K Articles by Cera, P J

TRANSITION OF BENIGN VAGINAL ADENOSIS TO CLEAR CELL CARCINOMA

From the Departments of Gynecology and Obstetrics and of Laboratory Medicine, Geisinger Medical Center, Danville, Pennsylvania

Abstract

The transition from benign adenosis to clear cell carcinoma of the vagina has not been established beyond doubt. The history of a patient regularly followed in a diethystilbestrol (DES) clinic shows initial benign adenosis with normal cytology and subsequent development of abnormal cytology and clear cell adenocarcinoma. The authors suspect transition from benign epithelium to malignancy; however, detailed serial histologic study failed to show clear transition. Frequent and thorough examination of DES patients is needed if malignant change is to be diagnosed early.