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Obstetrics & Gynecology 1983;61:121-126
© 1983 by The American College of Obstetricians and Gynecologists
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RESPONSE OF A MUCINOUS OVARIAN TUMOR OF BORDERLINE MALIGNANCY TO HUMAN CHORIONIC GONADOTROPIN

M A Quinn, MB, ChB, H W G Baker, MD, BS, PhD, R. Rome, MBBS, D. Fortune, MB, ChB and J B Brown, MSc, PhD, DSc

From the Department of Obstetrics and Gynaecology, University of Melbourne; the Royal Women's Hospital; and the Howard Florey Institute, Melbourne, Australia

Abstract

Plasma and urinary steroid hormones were measured before and after an injection of human chorionic gonadotropin (hCG) to a postmenopausal woman with a mucinous ovarian tumor of borderline malignancy. Hormones were also measured in blood from a vein draining the tumor, and circulating gonadotropins and plasma and urinary steroids were measured before and after tumor removal. Baseline levels of plasma progesterone (P), androstenedione ({Delta}2A), and estradiol (E2), and urinary estrogens and pregnanediol were high; they increased dramatically in response to hCG and fell after tumor removal. A less striking increase in testosterone, dihydrotestosterone, dehydroepiandrosterone (DHEA), and DHEA sulfate was noted after hCG injection. A gradient existed between tumor vein and peripheral vein levels of P, 17{alpha}-hydroxyprogesterone, {Delta}4A, E2, DHEA, and cortisol. Plasma follicle-stimulating and luteinizing hormones initially low but rose to the postmenopausal range after surgery. These results indicate the presence of {Delta} 4 and {Delta} 5 androstene pathways within the tumor. The responsiveness of the tumor to hCG provides further evidence that hCG may be the endogenous stimulus to steroid hormone production by epithelial ovarian tumors.






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Copyright © 1983 by the American College of Obstetricians and Gynecologists.