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Obstetrics & Gynecology 1983;61:117-121
© 1983 by The American College of Obstetricians and Gynecologists
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EFFECTIVE BROMOCRIPTINE TREATMENT OF A PITUITARY MACROADENOMA DURING PREGNANCY

Takayoshi Maeda, MD, Takahisa Ushiroyama, MD, Kiyoji Okuda, MD, Akira Fujimoto, MD, Minoru Ueki, MD and Osamu Sugimoto, MD

From the Department of Obstetrics and Gynecology, Osaka Medical College, Osaka, Japan

Abstract

A 32-year-old woman with 5 years of oligomenorrhea and 2 years of amenorrhea became pregnant after ovulation induced by clomiphene citrate, human menopausal gonadotropin, and human chorionic gonadotropin. Although there were no neurologic or ophthalmologic symptoms before pregnancy, ptosis and diplopia developed progressively from 14 weeks' gestation. Physical, radiologic, and laboratory examinations revealed hyperprolactinemia with pituitary macroadenoma. In an attempt to delay surgery, 7.5 mg bromocriptine was administered daily. The serum prolactin level was lowered and clinical symptoms improved with bromocriptine treatment. The pregnancy continued uneventfully and normal twins were born at 39 weeks' gestation. Two weeks after delivery, a transsphenoidal hypophysectomy was performed.




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M. P. Gillam, M. E. Molitch, G. Lombardi, and A. Colao
Advances in the Treatment of Prolactinomas
Endocr. Rev., August 1, 2006; 27(5): 485 - 534.
[Abstract] [Full Text] [PDF]




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