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Obstetrics & Gynecology 1981;58:753-759
© 1981 by The American College of Obstetricians and Gynecologists
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LONG-STANDING VIRILISM IN A WOMAN WITH HYPERPLASIA AND NEOPLASIA OF OVARIAN LIPIDIC CELLS

Bert J. Davidson, MD, Jerry Waisman, MD and Hotatrd L. Judd, MD

From the Departments of Obstetrics and Gynecology and of Pathology, UCLA School of Medicine, Los Angeles, California

Abstract

A woman with bilateral hyperplasia of ovarian hilar cells, stromal lipidic cells (hyperthecosis), and unilateral adenoma of Leydig cells is described. Her clinical course was characterized by long-standing virilism with a recent exacerbation suggesting growth of a tumor from the hyperplastic stromal lipidic cells. Evidence for this hypothesis included similar light and electron microscopic features of the hyperplastic and neoplastic cells and identical patterns of secretion of steroid hormones. Comparison of the in vivo steroid biosynthesis of the hyperplastic lipidic cells with that of testicular Leydig cells showed several similarities. These included 1) secretion of 5 and A4 steroids; 2) greater secretion of the A4 hormones, progesterone and 17-hydroxyprogesterone, than of the A5 steroids, pregnenolone and 17-hydroxypregnenolone; 3) prominent secretion of testosterone but not androstenedione; and 4) limited secretion of estrogens, with estradiol as the principal estrogen. These findings support prior microscopic evidence that ovarian lipidic cells and testicular Leydig cells represent cells of common function and, likely, common origin.




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 J. Clin. Endocrinol. Metab.Home page
R. B. Barnes and D. A. Ehrmann
Long-Term Suppression of Testosterone After Treatment with a Gonadotropin-Releasing Hormone Agonist in a Woman with a Presumed Testosterone Secreting Ovarian Tumor
J. Clin. Endocrinol. Metab., June 1, 1997; 82(6): 1746 - 1748.
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