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Cryotherapy in the Treatment of Cervical Intraepithelial Neoplasia

From the Department of Obstetrics and Gynaecology, Faculty of Medicine, University of British Columbia; and the Divisions of Gynaecology and of Pathology, Cancer Control Agency of British Columbia, Vancouver, British Columbia, Canada

Abstract

Cryotherapy was used to treat 516 patients with various degrees of dysplasia and carcinoma in situ over a 7-year period. Seventy-one percent of patients had either severe dysplasia or carcinoma in situ. In 88% of the patients treated, a single treatment session was successful in eradicating the lesion. Treatment was defined as successful when cytologic and colposcopic findings were negative 1 year after treatment. Five percent of patients were lost to follow-up. The criteria for selection of patients and possible causes of treatment failure are discussed.