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Obstetrics & Gynecology 1981;58:605-608
© 1981 by The American College of Obstetricians and Gynecologists
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Effect of Meconium Contamination on Amniotic Fluid Lecithin: Sphingomyelin Ratio

KHALIL M.A. TABSH, MD, CHARLES R. BRINKMAN, III, MD and RICHARD BASHORE, MD

From the UCLA School of Medicine, Department of Obstetrics and Gynecology, Los Angeles, California

Abstract

Studies on the lecithin: sphingomyelin (L:S) ratio in amniotic fluid were made before and after the addition of meconium in 130 normal pregnancies. The meconium was collected from premature and term infants after delivery. That which was collected from premature neonates had no significant effect on the mean L: S ratio of amniotic fluid; in 28% (17 of 60), however, the L: S ratio was elevated by 0.1 to 0.2, though in none by more than 0.2. When meconium collected from term neonates was added to amniotic fluid, it significantly increased the mean L:S ratio of amniotic fluid when the baseline L:S ratio was between 1.0 and 1.9 (P<.01); in 56% (39 of 70), the L:S ratios were elevated by 0.1 to 0.5, though none increased by more than 0.5. This study suggests that when amniotic fluid is contaminated with meconium, an L: S ratio of 2.2 in premature pregnancies and 2.5 or greater in term pregnancies retains its original predictive value.




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 Obstet GynecolHome page
S. S. Srouji, D. B. Carr, C. M. Gardella, T. Benedetti, and J. F. Tait
The Effect of Common Clinical Contaminants on Amniotic Fluid Fluorescence Polarization Results
Obstet. Gynecol., December 1, 2004; 104(6): 1237 - 1243.
[Abstract] [Full Text] [PDF]

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 Obstet GynecolHome page
T. S. Albright, D. F. Colombo, E. Euscher, and P. Samuels
Evaluation of the Effect of Meconium on Assessment of Fetal Lung Maturity Status by TDxFLM II Testing
Obstet. Gynecol., November 1, 2004; 104(5): 952 - 956.
[Abstract] [Full Text] [PDF]


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Copyright © 1981 by the American College of Obstetricians and Gynecologists.