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Adjunctive Radiation Therapy in the Management of Stage I Cancer of the Endometrium

From the Department of Obstetrics and Gynecology, University of Arizona, Tucson, Arizona; the Department of Obstetrics and Gynecology, Umea University, Umea; and the Radiumhemmet, Gynecology Section, Stockholm, Sweden

Abstract

One hundred fifty-two patients with stage I, grades 2 and 3 adenocarcinoma of the endometrium, treated in 1972 and 1973 at the Radiumhemmet, are presented. Two uterine packings followed at 4 to 6 weeks by total abdominal hysterectomy and bilateral salpingo-oophorectomy resulted in a 5-year survival of 89%, whereas patients treated primarily with surgery followed by vaginal cylinder irradiation demonstrated 90% survival. Patients in both groups received whole pelvis irradiation postoperatively for deep myometrial invasion (more than 50% invasion by viable tumor). Patients treated with radiation therapy alone had 57% survival. Optimal results in poorly differentiated (grade 3) carcinoma of the endometrium were achieved with preoperative packings (90% survival); only 12% of the patients required external radiation therapy postoperatively.

This article has been cited by other articles:

				M. F. WEISS, P. P. CONNELL, S. WAGGONER, J. ROTMENSCH, and A. J. MUNDT External Pelvic Radiation Therapy in Stage IC Endometrial Carcinoma Obstet. Gynecol., April 1, 1999; 93(4): 599 - 602. [Abstract] [Full Text] [PDF]