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Obstetrics & Gynecology 1981;58:247-250
© 1981 by The American College of Obstetricians and Gynecologists
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AZATHIOPRINE TERATOGENICITY: REVIEW OF THE LITERATURE AND CASE REPORT

Roger A. Williamson, MD and Laurence E. Karp, MD

From the Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, Washington

Abstract

An infant born with preaxial polydactyly to a mother taking azathioprine throughout pregnancy is described. Experimental studies in animals reveal a teratogenic role for azathioprine and its main metabolite, 6-mercaptopurine. The skeletal system appears to be the primary tissue target for such action of these drugs. Although no direct cause-effect relationship can be established from the single case presented, the similarity of this anomaly to experimental azathioprine teratogenesis suggests the necessity for further surveillance.




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