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ULTRASONOGRAPHIC PARAMETERS IN THE PRENATAL DIAGNOSIS OF MECKEL SYNDROME

From the Divisions of Maternal-Fetal Medicine and of Medical Genetics, Department of Obstetrics and Gynecology, Division of Diagnostic Ultrasonography, and Department of Radiology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania

Abstract

The ability to make a prenatal diagnosis of Meckel syndrome (encephalocele, polydactyly, and polycystic kidney) by ultrasound is described. Three cases are detailed; in 2 of these the diagnosis was made at 18 and 36 weeks' gestation, respectively. In case 1 Meckel syndrome was identified by the presence of oligohydramnios, microcephaly, and enlarged cerebral ventricles. In case 2 oligohydramnios was associated with an encephalocele, bilateral renal enlargement, and polydactyly. In case 3 the diagnosis was excluded in a fetus at risk. The usefulness of ultrasound in making this diagnosis is discussed for cases in which the amniotic fluid u-fetoprotein value is normal, inconclusive, or unobtainable.

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				P. D. Saw, G. A. Rouse, and M. de Lange Meckel Syndrome: Sonographic Findings Journal of Diagnostic Medical Sonography, January 1, 1991; 7(1): 8 - 11. [Abstract] [PDF]

				C. A. D'Agostino, M. Matturri, and L. Voutsinas Meckel's Syndrome: A Case Report and Literature Review of the Prenatal Diagnosis Journal of Diagnostic Medical Sonography, July 1, 1990; 6(4): 224 - 228. [PDF]