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Intraarterial Pelvic Infusion Chemotherapy in Advanced Gynecologic Cancer

From the Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, al the University of Iowa College of Medicine, Iowa City, Iowa

Abstract

Fourteen patients with advanced localized gynecologic cancer were treated with 44 courses of intraarterial pelvic infusion chemotherapy. All patients received methotrexate with folinic acid rescue; 9 patients also received vincristine. Tumor regression was observed in 3 of 14 patients (21.4%). In 5 patients there were major complications related to 28 intraarterial catheter placements. Two patients developed leukopenia following chemotherapy. The value of intraarterial infusion chemotherapy in gynecologic cancer is limited. Its use in gynecologic oncology is discussed.

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