Obstetrics & Gynecology Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Obstetrics & Gynecology 1978;52:457-461
© 1978 by The American College of Obstetricians and Gynecologists
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by WELCH, W. R.
Right arrow Articles by HERBST, A. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by WELCH, W. R.
Right arrow Articles by HERBST, A. L.

Comparison of Histologic and Colposcopic Findings in DES-Exposed Females

WILLIAM R. WELCH, MD, STANLEY J. ROBBOY, MD, DUANE E. TOWNSEND, MD, FACOG, ANN B. BARNES, MD, FACOG, ROBERT E. SCULLY, MD and ARTHUR L. HERBST, MD, FACOG

From the Departments of Pathology and Obstetrics and Gynecology at Harvard Medical School, the James Homer Wright Pathology Laboratories at Massachusetts General Hospital, Vincent Memorial Hospital (Gynecologic Service of the Massachusetts General Hospital), Boston, Massachusetts, the Section of Gynecologic Oncology at the University of Southern California School of Medicine, Los Angeles, California, and the Department of Obstetrics and Gynecology at the University of Chicago, Chicago, Illinois

Abstract

A study was undertaken to evaluate the histologic alterations associated with two or the most abnormal colposcopic findings, mosaicism and punctation, that are commonly found in the vaginas and cervices of young women who have been exposed prenatally to diethylstilbestrol (DES). Four-fifths of 215 biopsy specimens from 171 exposed subjects with mosaicism or punctation disclosed metaplastic squamous epithelium, the presence of which is thought to reflect the repair of vaginal adenosis and cervical ectropion. Hyperkeratosis was observed in one-fifth of the specimens and was more frequent in lesions colposcopically graded I than II. Mild dysplasia was encountered in only one specimen. The findings indicate that the presence of squamous cell dysplasia cannot be predicted by the finding of Grade I or II mosaicism or punctation in the DES-exposed female despite the fact that these abnormal colposcopic patterns are associated with dysplasia in about 10% of cases when encountered in the cervix of the unexposed woman.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1978 by the American College of Obstetricians and Gynecologists.