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Oral Contraceptive Estrogen and Plasma Lipid Levels

From the Departments of Physiology and Banting and Best Medical Research at die University of Toronto, Toronto, Ontario, Canada

Abstract

Blood samples were obtained from 20 women, aged 18 to 30 years, before and during the use of selected oral contraceptives. The contraceptive preparation containing 100 µg mestranol induced increases in triglycerides, esterified cholesterol, free cholesterol, and phospholipids. Ethinyl estradiol with norgestrol, on the other hand, tended to decrease the lipid levels, while preparations containing only 50 µg mestranol produced no significant change in the levels of the four substances. The levels produced by each of these three preparations did not exceed the normal limits. A cyclic fluctuation was observed in the monthly cycles.