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ENHANCED RED CELL OXYGEN TRANSPORT IN A PREGNANT WOMAN WITH HEMOGLOBIN SD DISEASE

From the Naval Blood Research Laboratory, Boston, Massachusetts, and the Department of Obstetrics and Gynecology al the Naval Hospital. Chelsea. Massachusetts

Abstract

An anemic pregnant black primigravida with hemoglobin SD disease was studied throughout pregnancy and parturition. Hemoglobin SD disease was established by agar gel electrophoresis at pH 6.2. The patient carried to term a healthy female infant, an unusual occurrence in a patient homozygous for hemoglobin SD disease. The increase in the red cell concentration of 2,3 diphosphoglycerate (2,3 DPG) of 18-21 µ M/g Hb (normal 12 ± 2 µ M/g Hb) was associated with a decrease in red cell oxygen affinity. The patient's In vitro P50 value ranged between 35 and 45 mm Hg (normal 28 ± 1 mmHg). The function of red cells with increased 2,3 DPG levels and decreased affinity for oxygen in a pregnant woman with hemoglobin SD disease is discussed.