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Obstetrics & Gynecology 1978;52:349-354
© 1978 by The American College of Obstetricians and Gynecologists
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The Use of Adriamycin and Methotrexate in Carcinoma of the Cervix

The Development of a Safe Effective Regimen

D. GUTHRIE, MB, BS, MRCOG and S. WAY, FRCS, FRCOG

From the Department of Gynaecological Oncology at Queen Elizabeth Hospital, Gateshead, England, and the Department of Obstetrics and Gynaecology at the University of Newcastle upon Tyne, England

Abstract

The results of treating 59 patients with advanced carcinoma of the cervix with Adriamycin and methotrexate are given. Five combinations of the two cytotoxic drugs have been evaluated, differing only with regard to the methotrexate. One particular regimen has been shown to be effective with a relatively high remission rate coupled with a low rate of side effects.






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