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Pregnancy-Specific Beta-1-Glycoprotein Levels in Cholestasis of Pregnancy

From the Department of Bacteriology and Immunology at the University of Helsinki and the Departments I and II of Obstetrics and Gynecology at the University Central Hospital, Helsinki. Finland. Supported by grants from the Association of the Finnish Life Insurance Companies, the Finnish Cancer Society, and the Medical Research Council, Academy of Finland

Abstract

Plasma concentrations of pregnancy specific ß-1-glycoprotein (PSBG) were measured by specific radioimmunoassay in 211 samples from 123 normal women during the third trimester of pregnancy and in 166 samples from 68 patients with cholestasis of pregnancy. At 37-38 weeks of gestation patients with cholestasis had significantly lower PSBG levels than the normal pregnant women (P< 0.005), whereas the levels in patients in the cholestasis had not been significantly different from those for normal pregnant women before 37 weeks. At 37-38 weeks of gestation patients with cholestasis showed a slight correlation between placental weight and plasma PSBG levels (r= 0.362; P< 0.05), whereas this was not found in patients with normal pregnancy. No correlation was found between infant weight or length at birth and the PSBG concentrations in either group, and no difference was noted in PSBG concentrations between cases with and without fetal distress.