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Obstetrics & Gynecology 1978;52:94-96
© 1978 by The American College of Obstetricians and Gynecologists
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Podophyllin Poisoning

Systemic Toxicity Following Cutaneous Application

GERALD E SLATER, MD, BARRY H RUMACK, MD and ROBERT G PETERSON, MD, PhD

From the Departments of Pediatrics, Medicine, and Pharmacology al the University of Colorado Medical Center, Rocky Mountain Poison Center, Denver General Hospital, Denver, Colorado

Abstract

The toxicity of topically applied podophyllin in a 16-year-old girl is presented. Coma requiring respiratory support and major neurologic complications as well as hematologic and hepatic toxicity was observed. Therapy with a new modality, charcoal hemoperfusion, resulted in resolution of the acute toxicity, leaving a peripheral neuropathy which had not completely resolved after 4 months. The pharmacology and suggested treatment measures for the toxicity of this rarely reported agent are reviewed






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