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Obstetrics & Gynecology 1978;51:225-228
© 1978 by The American College of Obstetricians and Gynecologists
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Immunosuppressive Effect of Serum in Patients With Ovarian Carcinoma

KATSUMA UEDA, MD, MOTOKAZU TOYOKAWA, MD, HIROSHI NAKAMORI, MD, HISAO SAKO, MD, NAOHIKO UMESAKI, MD, JYUNKO NAKADE, MD, TOHMAN LEE, MD. and TADASHI SUGAWA, MD

From the Department of Obstetrics and Gynecology at Osaka City University Medical School. Osaka, Japan.

Abstract

Cell-mediated immune response was measured in 23 patients with ovarian cystadenocarcinoma, 38 patients with benign ovarian tumor, and 44 healthy volunteers. The method used two indexes: the lymphocyte response per unit volume of peripheral blood to phytohemaggluttnin (PHA) and the immunosuppressive effect of serum on the response of normal lymphocytes to PHA stimulation. The lymphocyte response per 50 µl peripheral blood did not differ significantly between patients with ovarian cancer and healthy volunteers. The serum effect, in contrast, differed significantly between malignant and benign ovarian tumors, and was found to increase significantly even when the cancer masses were as small as about 5 X 5 X 5 cm in size, ie, in FIGO Stage 1. It is our belief that the measurement of the serum effect in patients with any ovarian tumor enables the early detection of ovarian cancer.






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Copyright © 1978 by the American College of Obstetricians and Gynecologists.