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Obstetrics & Gynecology 1978;51:210-213
© 1978 by The American College of Obstetricians and Gynecologists
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Origin of Estrogen In Isosexual Precocious Pseudopuberty Due To A Granulosa-Theca Cell Tumor

JAMES D. MADDEN, MD, FACOG and PAUL C. MacDONALD, MD, FACOG

From the Cecil H. and Ida Green Center for Reproductive Biology Sciences and the Department of Obstetrics and Gynecology at The University of Texas Southwestern Medical School Dallas, Texas.

Abstract

The purpose of the present study was to quantify the rates of production and to define the mechanism(s) of origin of sex steroid hormones in a 3 1/2-year-old girl with isosexual precocious pseudopuberty caused by a granulosa-theca cell tumor of the ovary. The results suggest that the hyperestrogenism occurs principally due to the secretion of estradiol-17ß synthesized de novo by the tumor, but that the tumor in vivo was also capable of aromatizing C19 plasma precursor hormones to estrogen.






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Copyright © 1978 by the American College of Obstetricians and Gynecologists.