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Obstetrics & Gynecology 1978;51:38
© 1978 by The American College of Obstetricians and Gynecologists
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Endometrial Stromal Sarcoma Arising From Vaginal Endometriosis

ROSS S. BERKOWITZ, MD, ROBERT L. EHRMANN, MD and ROBERT C. KNAPP, MD, FACOG

From the Departments of Obstetrics and Gynecology and Pathology at Harvard Medical School, Boston Hospital for Women, Boston, Massachusetts.

Abstract

The present case reports the concurrence of endometriosis of the vaginal cuff with endometrial stromal sarcoma in association with high-dose estrogen. This case raises the question of whether chronic high-dose estrogen might be associated with malignant transformation of endometrial stroma. Although there is no definitive evidence of a causal relation between estrogen and endometrial stromal sarcoma, the possibility should be explored further. Therapy of this neoplasm is discussed and salient clinical and pathologic features are reviewed.






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Copyright © 1978 by the American College of Obstetricians and Gynecologists.