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Obstetrics & Gynecology 1978;51:89-92
© 1978 by The American College of Obstetricians and Gynecologists
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Absence of Capillary Microangiopathy in Oral Contraceptive Users With Glucose Intolerance

JOSEPH W. GOLDZIEHER, MD, HILDA VILLEGAS-CASTREJON, MD, ALEJANDRO CERVANTES, MD, PhD, MANUEL MAQUEO, MD and MARVIN D. SIPERSTEIN, MD

From the Southwest Foundation for Research and Education at San Antonio, Texas, the Instituto Mexicano del Seguro Social at Hospital de Gineco-Obstetricia No. Uno, and the Asociacion Pro-Salud Maternal at Mexico, D.F., Veterans Administration Hospital and Department of Medicine at University of California, San Francisco, California.

The possible vascular hazard associated with carbohydrate intolerance produced by long-term use of oral contraceptives was investigated by examining the capillary basement membrane thickness in quadriceps muscle biopsies, a highly sensitive and reliable indicator of diabetic microangiopathy. The average basement membrane thickness of 18 long-term (4–9 years) contraceptive users with diminished carbohydrate tolerance was 1644 A, compared to normal pregnant women (1711 A) prediabetic pregnant women (1854 A), and overt diabetic women (2593 A). Contraceptive steroid-induced carbohydrate intolerance appears to carry little, if any, increased risk for the development of diabetic vascular disease, even as assessed by the sensitive electron microscopic technique.






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Copyright © 1978 by the American College of Obstetricians and Gynecologists.