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Induction of Labor in the High-Risk Pregnancy With PGF₂

From the Department of Obstetrics and Gynecology at New York Medical College, New York, New York.

The induction of labor in the high-risk patient is accompanied by an increased incidence of cesarean section partly due to failed induction. A series of 50 high-risk patients induced with intravenous prostaglandin F₂ is presented. Forty-five were successfully induced, 35 of whom delivered vaginally. Failed inductions occurred in 5 patients. The overall success rate was 90%, and cesarean section rate was 25.5%. There was an increased incidence of late decelerations in the PGF₂ group as compared to spontaneous and Pitocin-stimulated labors. While the success was high, the use of a drug which itself may cause fetal cardiovascular changes is not desirable, especially in those pregnancies already at risk.