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Obstetrics & Gynecology 1976;48:491-494
© 1976 by The American College of Obstetricians and Gynecologists
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RECURRENCE OF VULVOVAGINAL CANDIDOSIS DURING PREGNANCY

Comparison of Miconazole vs NystatinTreatment

Henk C.S. Wallenburg, MD, PhD and Juriy W. Wladimiroff, MD, PhD

From the Department of Obstetrics and Gynccology at the Academish Ziekenhuis Universiteit Rotterdam, The Netherlands

The efficacy of miconazole and nystatin in the treatment of vulvovaginal candidosis was compared in a multiccnter trial involving 9-1 pregnant patients. All patients had subjective complaints and were mycologically positive. Miconazole 2% vaginal cream was applied once daily for at least 10 days by 45 patients, whereas the 49 others received nystatin tablets for intravaginal application during 7 to 9 days. At the first examination following treatment, the cure rate with miconazole was 83% and with nystatin 68%. Follow-up examinations revealed a significantly lower recurrence rate in the miconazolc-trcatcd group. No important adverse experiences were noted.






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Copyright © 1976 by the American College of Obstetricians and Gynecologists.