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Concurrent Use of Prostaglandin F₂ and Laminaria Tents for Induction of Midtrimester Abortion

From the Cecil H. and Ida Green Center for Reproductive Biology Sciences and the Department of Obstetrics and Gynecology. The University ofTexas Southwestern Medical School. Dallas. Texas

Abstract

One hundred sixteen women between 14 and 20 weeks of gestation were aborted with a combined regimen of intraamniolic prostaglandin F_2a (PGF_2a) and intracervical laminaria. Complications among these women were compared to those among 122 patients who aborted after PGF_2a administration only. Shorter intervals between initiation and completion of abortion were observed in nulliparous women treated with the combined regimen than in nulliparous women treated with PGF_2a only. In parous patients, the use of laminaria did not shorten the interval from initiation to completion of abortion. A decrease of the hematocrit in excess of 5 points and pcriabortal infection requiring antibiotic therapy occurred with similar frequency in both treatment groups. However, with the combined regimen no cervical tears were observed in nulliparous patients, and fewer women failed to abort within 48 hours.