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Obstetrics & Gynecology 1976;47:463-468
© 1976 by The American College of Obstetricians and Gynecologists
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Chromosome Studies in Couples With Repeated Spontaneous Abortions

CHRISTINA TSENGHI, MD, CATHERINE METAXOTOU-STAVRIDAKI, MD, MARIA STRATAKIBENETOU, MD, ARIADNI KALPINI-MAVROU and NICHOLAS MATSANIOTIS, MD

From the First Department of Petiatries ut Athens University. Athens. Greece

Abstract

Karyotypes were prepared from peripheral blood leukocytes in 77 couples in whom there was no apparent cause for recurrent spontaneous abortion. In addition to conventional staining, chromosomes were stained by the new technics for Q-, G-, or C-banding. Translations were found in 5 of 154 persons (3.25% or 1:31 individuals). The frequency of translocations in the general adult population is 0.4% (1:255). Two translocations were apparent only with the new technics for banding. The incidence of chromosomal microanomiilics was 7.79% (2.6% in the general population). Karyotyping of couples with recurrent abortion is recommended, with use of the new staining technics.






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