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Growth Hormone Secretion in Insulin-Independent Pregnant Diabetics

From thc Department of Obstetrics and Gynecology at the University of Florida College of Medicine. Gainesville. Florida and thc Department of Pharmacology at the University of Durban-Westville, Durban, South Africa

Abstract

A study was initialed to determine whether hypersecreliun of growth hormone (HGH) was involved in the inhibition of normal glucose metaholism in pregnant insulin-independent diabetics (HD). A total of 25 patients was studied, of whom 13 had normal glucose tolerance and 12 were recently diagnosed HDs. HGH secretion was stimulated by insulin-induced hypoglycemia. The mean basal HGH levels and the plasma HGH pattern following the insulin stimulus were similar in the study group and the normal controls. Although it is unlikely that HGH participates to any significant degree in the diabctogenicity of normal and diabetic pregnancy, final proof depends on the assessment of the biologically active inhibitory polypeptide fraction of HGH and the growth-promoting protein, somatomedin.