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Human Placental Lactogen and Intrauterine Growth Retardation

From the Department of Obstetrics and Gynecology at the University of Florida College of Medicine, Gainesville, Florida

Abstract

Serum human placental lactogen levels were measured after 36 necks' gestation in 264 serum samples from 109 women with normal pregnancies and in 137 serum samples from 70 women with pregnancies complicated by fetal intrauterinc growth retardation (IGR). The fetal and placental weights were significantly lower in the IGR group while the maternal ages were not different. There was a significantly lower hPL value at each week from 36 to 41 (except for the 39th) in the IGR group. Sixty percent of the women with IGR had hPL values less than 6 µg/ml, and 18.6% were less than 4 µg/ml. It is suggested that a low serum hPL value obtained during the last month of pregnancy should alert the physician to the possibility of intraulerine problems, including IGR.