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Cephacetrile in the Treatment of Female Pelvic Inflammatory Disease

From the Department of Obstetrics and Gynecology at Louisiana State University School of Medicine. New Orleans. Louisiana

Abstract

The efficacy and lolcrabilily of cephacetrilc administered by the intravenous or intramuscular route nas evaluated in an openlabel study of 55 hospitalized females diagnosed as having mild to severe pelvic inflammatory disease. Rapid improvement was observed in most patients. All patients were classified as clinically cured or significantly improved. Pain was absent or mild in S6'r of the patients who received cephacetrilc by intramuscular injection. Seventy-two percent of the patients given the drug intravenously experienced no localized pain. Phlebitis occurred in 6 of the 53 patients (11%) who received intravenous cephacetrile and thrombosis was present in 3 (6%). Rash and pruritus was reported in 1 patient. Results of this study suggest that cephacetrilc is an important and useful drug in the treatment of pelvic inflammatory disease.