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Obstetrics & Gynecology 1976;47:415-418
© 1976 by The American College of Obstetricians and Gynecologists
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Induction of an LH Surge with Estradiol Benzoate

A Clinical Test of Pituitary-Hypothalamic Axis Competence

GERSON WEISS, MD, FACOG, LILA E. NACHTIGALL, MD and MANIK GANGULY, PhD

From the Department of Obstetrics and Gynecology at New York University School of Medicine, New York, New York

Abstract

Intramuscular injection of 6.6 mg of estradiol benzoate (EB) in oil was used in 34 women as a test of the ability of the pituitary-hypothalamic axis to produce a gonadotropin surge (positive feedback response). These responses were compared to Clomid responses. AH of the normal cycling women, two-thirds of oligo-ovulatory but menstruating women, and one-third of amenorrheic women had LH surges to EB challenge. Estradiol benzoate is a more specific test of positive feedback response than Clomid. It also may be effective in inducing ovulation in some amenorrheic patients refractory to Clomid treatment.




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