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Metabolic Clearance Rate of Dehydroisoandrosterone Sulfate VI. Studies of Eclampsia

Cecil H. and Ida Green Center for Reproductive Biology Sciences and Department of Obstetrics and Gynecology at The University of Texas Southwestern Medical School, Dallas, Texas.

The metabolic clearance rate of dehydroisoandrosterone sulfate (MCR_DS) was measured in 11 women during an eclamptic episode, and the subjects were then followed for at least 5 years. The MCR_DS was usually decreased in primigravid women with eclampsia. However, in eclamptic primigravid women who later developed essential hypertension and/or recurrent hypertension in subsequent pregnancies the MCR_DS was elevated. Also, in multiparous women with chronic essential hypertension plus superimposed eclampsia, the MCR_DS was increased to above normal values.

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