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Metabolic Clearance Rate of Dehydroisoandrosterone Sulfate V. Studies of Essential Hypertension Complicating Pregnancy

Cecil H. and Ida Green Center for Reproductive Biology Sciences and Department of Obstetrics and Gynecology at The University of Texas Southwestern Medical School, Dallas, Texas.

The metabolic clearance rate of dehydroisoandrosterone sulfate (MCR_DS) was determined prospectively in gravidas with and without chronic essential hypertension. In normotensive patients, the MCR_DS increased in a linear fashion throughout pregnancy. In patients with chronic essential hypertension the MCR_DS also increased progressively, but at higher values than in normotensive subjects. In normotensive gravidas who ultimately developed pregnancy-induced hypertension, the MCR_DS increased progressively at a higher level than in gravidas who remained normotensive until approximately 4 weeks prior to the onset of clinical symptoms, at which time the MCR_DS slowly decreased. Similarly, in gravidas with chronic hypertension who developed superimposed pregnancy-induced hypertension, the MCR_DS increased progressively at higher levels than all groups studied until approximately 4 weeks prior to the onset of hypertension, when a progressive decline in the MCR_DS began.

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