HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by SPELLACY, W. N. Articles by BUHI, W. C. Search for Related Content PubMed PubMed Citation Articles by SPELLACY, W. N. Articles by BUHI, W. C.

Glucagon, Insulin and Glucose Levels in Maternal and Umbilical Cord Plasma With Studies of Placental Transfer

Department of Obstetrics and Gynecology at the University of Florida College of Medicine, Gainesville, Florida.

Plasma immunoreactive glucagon, as well as insulin and glucose levels, was measured in 62 women and their infants following a term gestation vaginal delivery. Simultaneously obtained samples were drawn from the maternal antecubital vein (MV), umbilical vein (UV), and umbilical artery (UA). Forty-seven of these subjects were untreated (control) and 15 had received a maternal intravenous injection of 1 mg of glucagon within 40 minutes of delivery. It was shown that the umbilical cord glucagon levels were not different from the maternal levels in the control subjects (mean MV, 181.0; UV, 191.9; UA, 161.0 pg/ml). There was no correlation between the maternal and umbilical glucagon levels or the UV glucagon levels and the insulin or glucose concentrations. Neither the fetal sex, placental weight, or infant weight were correlated with the MV or UV glucagon concentration. Following the glucagon injection, the maternal plasma glucagon levels rose significantly, whereas the umbilical blood values did not change. These results suggest that glucagon does not significantly pass through the human term placenta.

This article has been cited by other articles:

				R. A Hiles, R. E Bawdon, and E. M Petrella Ex vivo human placental transfer of the peptides pramlintide and exenatide (synthetic exendin-4) Human and Experimental Toxicology, December 1, 2003; 22(12): 623 - 628. [Abstract] [PDF]