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Obstetrics & Gynecology 1976;47:287-290
© 1976 by The American College of Obstetricians and Gynecologists
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Prenatal Sex Determination by Observation of the X-Chromatin and the Y-Chromatin of Exfoliated Amniotic Fluid Cells

KAP SOON JU, MD, PhD, I. JAMES PARK, MD, FACOG, HOWARD W. JONES, JR., MD, FACOG and KEVIN J. WINN, MD

Cytogenetics Laboratory of the Department of Obstetrics and Gynecology and the Department of Pathology of The Johns Hopkins University School of Medicine, Baltimore, Maryland.

Using direct smears of amniotic fluid cells fixed by the flame drying technic, the validity of sex determination by X-chromatin and Y-chromatin counts has been examined. In 112 cases, the sex determination by examination of the X-chromatin was correct in 109 (97%) and was correct by the Y-chromatin technic in 111 (99%). It is concluded that prenatal sex determination by examination of the X-chromatin or the Y-chromatin from fresh amniotic fluid cells is a valuable, rapid, practical method of prenatal sex determination.






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Copyright © 1976 by the American College of Obstetricians and Gynecologists.