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Obstetrics & Gynecology 1976;47:282-286
© 1976 by The American College of Obstetricians and Gynecologists
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Studies of Maternal Plasma Prolactin and Amniotic Fluid Prolactin Effects of Chlorpromazine and Prostaglandin F2{alpha}

RUTH FREEMAN, MD, MICHAEL LEV-GUR, MD, ROBERT M. BOYAR, MD and HAROLD SCHULMAN, MD, FACOG

Endocrine Division of the Department of Obstetrics and Gynecology at the Albert Einstein College of Medicine and the Department of Oncology at Montefiore Hospital and Medical Center. Bronx, New York.

We have studied the effect of chlorpromazine and PGF2{alpha} on the blood and amniotic fluid levels of prolactin over a 1-hour period of time in women who were in the 14th-20th week of gestation. Following intramuscular injection of chlorpromazine, maternal plasma prolactin rose 1.0– to 2.5-fold. No significant change was noted in maternal plasma after PGF2{alpha} administration. Amniotic fluid protactin declined by 6 to 56%. These changes may be dilutional.






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