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Obstetrics & Gynecology 1976;47:218-222
© 1976 by The American College of Obstetricians and Gynecologists
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Pharmacologic Influences on Human Ovarian Contractions

MARTHA F. GIMENO, MD, ENRI BORDA, MD, LEONOR STERIN-BORDA, MD, JORGE H. VIDAL, MD and ALVARO L. GIMENO, MD

Centro de Estudios Farmacologicos y de Principios Naiurales and the Institute de Neurobiologia, Buenos Aires. Argentina.

Spontaneous motility in whole ovarian follicles, as well as in strips from the stroma and capsule of ovaries isolated from premenopausal and menopausal women, was explored. The pharmacologic contractile reactivity of these ovarian structures to different smooth muscle-stimulating agents, ie, prostaglandins E1, E2, F2{alpha} norepinephrine; 5-hydroxytriptamine; acetylcholine; phenylephrine; and phentolamine, was also studied. Strips from the capsule and stroma of isolated ovaries showed spontaneous motility in both menopausal and nonmenopausal preparations. The addition of phenylephrine, norepinephrine, acetylcholine, 5-HT, or PGF2{alpha} induced a sustained tonic contractile tension, whereas PGE, elicited the opposite influence. Stromal strips from nonmenopausal women showed more reaction to norepinephrine than those from menopausal ones. Ovarian follicles did not exhibit spontaneous motility but responded lo added norepinephrine. This influence was blocked by phenlolamme, indicating the eventual participation of alphaadrenergic receptors. Acetylcholine, PGF2{alpha} and, to a smaller extent, PGE2, also increased follicular resting tension. On the contrary, PGE, was clearly inhibitory both upon the spontaneous basal tone and the PGF2{alpha}-induced sustained contractions.






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